Job Description
Job DescriptionWhy Work With Us?At Candel Therapetics, our people drive our success. We value diversity, collaboration, and bold thinking in a supportive, mission-driven environment. Like a team, we show up for each other and stay focused on making a difference for patients and families. Our leadership is transparent and empowering, and our culture is built on trust, flexibility, and accountability, encouraging ownership and innovation every day.Our Science: Advancing Cancer ImmunotherapiesCandel Therapeutics is a clinical-stage biopharma company developing off-the-shelf, multimodal immunotherapies that stimulate personalized, systemic anti-tumor responses. Our platforms use genetically modified adenovirus and HSV constructs. With positive Phase 3 results for our lead candidate, it’s an exciting time to join us and help bring transformative cancer treatments to patients. Learn more: www.candeltx.comPosition Summary:We’re looking for a Clinical Trial Manager (CTM) to help us lead execution of our Phase 3 oncology trials with precision, confidence, and heart. This is a fast-paced, high-accountability role where you’ll collaborate cross-functionally, ensure inspection readiness, and keep our clinical operations running smoothly.
If you’re a self-motivated leader who thrives on solving problems, navigating complexity, and working with humility, this role is for you.What You’ll Do:
- Provide operational management and leadership to cross-functional study team to execute the clinical study per agreed upon timelines, budget and quality.
- Drive startup through closeout: IRB, contracting, site selection, initiation, monitoring, and metrics tracking.
- Support inspection readiness and contribute to critical regulatory milestones.
- Co-monitor with CRAs; review site visit reports and escalate issues proactively.
- Maintain essential documents and trial master file (TMF) accuracy.
- Collaborate with internal teams and vendors to ensure alignment and effective execution.
What You Bring:
- 4+ years of CTM or site management experience in oncology clinical trials is required
- Deep understanding of Phase 3 trial conduct and in-house operational models
- Familiarity with ICH/GCP, FDA/EMA guidelines, and regulatory best practices
- Strong leadership and problem-solving skills; ability to manage ambiguity and prioritize independently
- Exceptional communication skills and comfort interacting with senior stakeholders
- Prior CRA experience is a plus
- High emotional intelligence and a “scrappy but humble” mindset
Why You’ll Succeed at Candel:
- You know how to get things done without needing step-by-step instructions
- You value collaboration over ego and strive to lift others as you grow
- You’re excited to join a growing company and make a tangible impact
- You care about patients, science, and people—in that order
Work Environment:This is a hybrid position based in the Greater Boston area. Onsite presence of 1–2 days/week is expected. Occasional travel (~20%) may be required for site co-monitoring or inspections.
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