Analytical Chemist - Hybrid

Connexion Systems & Engineering, Inc.

Boston, MA, USA

Published: 6/14/2022

Science

Full Time

Job Description

Connexion’s mission is to provide "best in class" services to job seekers. We strive to achieve excellence in job placement, staffing, and recruiting services, while treating candidates with the professionalism and respect they deserve.

Title: Analytical Chemist

Job Location: Boston, MA (Hybrid – 3 days onsite)
Schedule: M-F, 1st shift

Description:
We are seeking an experienced Analytical Chemist to support late-stage development activities within a Technical Operations Analytical team. This role will focus on providing analytical support for oligonucleotides, peptides, and peptide-oligonucleotide conjugates, with a strong emphasis on method development, transfer, and validation in a GMP environment.

Key Responsibilities

Provide analytical support for oligonucleotide and peptide-oligonucleotide conjugated compounds in late-stage development
Independently lead analytical method development, transfer, and validation activities
Develop and optimize robust analytical methods including LC/MS, IP-RP HPLC, and SAX HPLC for highly modified oligonucleotide drug substances
Perform analysis and purification using techniques such as UPLC, LC-MS, and LC-MS/MS
Operate, maintain, and troubleshoot analytical instrumentation
Ensure compliance with GLP/GMP standards and documentation requirements
Author technical reports, protocols, and validation documentation
Collaborate effectively with cross-functional teams while working independently as an analytical subject-matter expert

Qualifications

BS or MS in Chemistry or a related scientific discipline
5+ years of commercial, GMP analytical laboratory experience
Hands-on experience with oligonucleotide therapeutics is required
Strong background in analytical method development and validation
Proficiency with mass spectrometry and purification techniques
Experience with RP-HPLC, SAX-HPLC, UPLC, and LC-MS
Familiarity with instrumentation from Agilent, Waters, and/or Thermo and associated software
Excellent written and verbal communication skills
Proven ability to work independently and as part of a collaborative team

This is a great opportunity for an analytical expert looking to make an immediate impact on late-stage drug development programs in a fast-paced, GMP-driven environment.