Purification Scientist - Biologics / Viral Vectors

Job Description

Job Description

Job Title: Biologist
Location: Boston, MA 02210
Work Schedule: Monday–Friday, 8:00 AM – 5:00 PM

Job Overview:

We are seeking a highly motivated Biologist to join our Downstream Process Development team. The candidate will contribute to the purification and characterization of viral vectors, biologics, or recombinant proteins, supporting process development and manufacturing activities.

Key Responsibilities:

• Execute purification processes including affinity chromatography (e.g., AVB, CaptureSelect) and ion-exchange chromatography (AEX, CEX).

• Operate AKTA systems (Avant, Pure, or Pilot) for small- to large-scale purification runs.

• Perform tangential flow filtration (TFF) for buffer exchange and product concentration.

• Support experimental design, data collection, and documentation following GMP/GLP guidelines.

• Troubleshoot and optimize purification processes.

• Analyze samples using relevant methods (UV, SDS-PAGE, ddPCR, ELISA, HPLC).

• Collaborate cross-functionally with upstream, analytical, and manufacturing teams.

• Maintain lab equipment, buffers, column inventory, and compliance with safety standards.

Qualifications:

Education:

• Master’s degree in Biochemistry, Chemical Engineering, Biotechnology, or related field.

Experience:

• Minimum 2 years of hands-on purification experience in academic or industry settings.

Technical Skills:

• Strong experience with ion-exchange and affinity chromatography.

• Familiarity with buffer preparation.

• Knowledge of basic analytical methods for product characterization.

Soft Skills:

• Strong attention to detail and excellent documentation habits.

• Effective communication and teamwork skills.

• Ability to manage multiple tasks and meet project timelines.

Preferred Qualifications:

• Experience in AAV or other viral vector purification.

• Experience with AKTA systems and Unicorn software.